School of Computing

Design principles of transcriptional logic circuits

Nicolae Radu Zabet, Andrew N. W. Hone, and Dominique F. Chu

In Artificial Life XII Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems, pages 182-196. MIT Press, August 2010 Freely available for download at: http://mitpress.mit.edu/catalog/item/default.asp?ttype=2&tid=12433.

Abstract

Using a set of genetic logic gates (AND, OR and XOR), we constructed a binary full-adder. The optimality analysis of the full-adder showed that, based on the position of the regulation threshold, the system displays different optimal configurations for speed and accuracy under fixed metabolic cost. In addition, the analysis identified an optimal trade-off curve bounded by these two optimal configurations. Any configuration outside this optimal trade-off curve is sub-optimal in both speed and accuracy. This type of analysis represents a useful tool for synthetic biologists to engineer faster, more accurate and cheaper genes.



Bibtex Record

@inproceedings{3036,
author = {Nicolae Radu Zabet and Andrew N. W. Hone and Dominique F. Chu},
title = {Design Principles of Transcriptional Logic Circuits},
month = {August},
year = {2010},
pages = {182-196},
keywords = {determinacy analysis, Craig interpolants},
note = { Freely available for download at: http://mitpress.mit.edu/catalog/item/default.asp?ttype=2&tid=12433},
doi = {},
url = {http://www.cs.kent.ac.uk/pubs/2010/3036},
    publication_type = {inproceedings},
    submission_id = {26290_1282835570},
    booktitle = {Artificial Life XII Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems},
    publisher = {MIT Press},
}

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